Osage University Partners II has received $151m in commitments from 145 LPs according to a filing with the US Securities and Exchange Commission.
The funds predecessor was a $100m vehicle which closed in 2011.
Fund II will focus on start-ups that are commercialising university research.
The vehicle will invest in cleantech, energy, IT, biopharma, healthcare IT, medical devices and diagnostics and tech-enabled services.
Osage will commit between $5m and $6m per investment.
It portfolio companies include family robot Jibo, big data analytics company Skytree and novel therapeutics research company AGTC.